The cGAS–STING pathway as a therapeutic target in ... - Nature
Apr 8, 2021 · We briefly summarize the current state of understanding of signalling through the cGAS–STING pathway, outline molecular mechanisms that trigger cGAS–STING pathway activity in distinct ...
cGAS-STING 信号通路发现史（上） - 知乎专栏
在STING发现以前，大量的研究已经表明两类重要的转录因子（transcription factors），一个是 NF-kB，另一个是 IRF3，这两个转录因子都能在病毒入侵时诱导一系列基因表达谱发生改变以产生病毒抵抗。 其中，NF-KB主要是诱导 促炎性细胞因子 表达，而IRF3主要是诱导 I型干扰素 表达。 图片Ref: Toll-Like Receptors and Viral Infection | Review | InvivoGen. NF- κ B. NF-kB家族主要包括NF-κB1 (also named p50), NF-κB2 (also named p52)， RelA (also named p65)， RelB 和 …
Molecular mechanisms and cellular functions of cGAS–STING signalling
May 18, 2020 · The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes (STING), detects...
Advances in cGAS-STING Signaling Pathway and Diseases
Feb 2, 2022 · The cyclic GMP–AMP synthase (cGAS) stimulator of interferon gene (STING) signaling pathway is a critical natural immune pathway in cells. Early studies revealed that it plays a crucial regulatory role in pathogen infection and tumor, and it is associated with various human autoimmune diseases.
The balance of STING signaling orchestrates immunity in cancer
Jun 25, 2024 · Over the past decade, it has become clear that the stimulator of interferon genes (STING) pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored adaptor...
Current understanding of the cGAS-STING signaling pathway: …
Jan 18, 2023 · The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream signaling adaptors, plays an essential role in protective immune defense against microbial DNA and internal damaged-associated DNA and is responsible for various immune-related diseases.
Cellular functions of cGAS-STING signaling - Cell Press
Nov 24, 2022 · Cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) signaling possesses widespread interferon-independent activities, and controls diverse cellular functions. cGAS-STING signaling also controls autophagy, translation, metabolism, condensation, senescence, cell death, and fibrotic and neurodegenerative diseases.
New frontiers in the cGAS-STING intracellular DNA-sensing pathway
Apr 9, 2024 · The cGAS-STING intracellular DNA-sensing pathway has emerged as a key element of innate antiviral immunity and a promising therapeutic target.
cGAS–STING, an important signaling pathway in diseases and …
Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway is the main mediator of DNA-triggered immune response in mammalian cytoplasm. cGAS mainly recognizes and binds double-stranded deoxyribonucleic acid (dsDNA) from pathogens or humans themselves.
cGAS-STING signaling - PubMed
Jul 11, 2022 · Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) and synthesizes cy …
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