Mechanisms of type-I- and type-II-interferon-mediated signalling …
May 1, 2005 · Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects. Because of these important properties, in the past two decades, major research efforts have been...
IFNγ: signalling, epigenetics and roles in immunity ... - Nature
Jun 19, 2018 · Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated...
Regulation of type I interferon responses - Nature
Dec 23, 2013 · Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus...
Interferon (IFN) Cell Signaling Pathway - Thermo Fisher Scientific
The interferon (IFN) pathway plays a critical role in the human immune response. Following viral infection, the human body triggers a complex regulatory system of innate and adaptive immune responses designed to defend against the virus.
The Type I Interferons: Basic Concepts and Clinical Relevance in …
Schematic diagram shows major signaling pathways stimulated by IFN-α/β (mediated by the type I IFN receptor) and viral pathogen-associated molecular patterns (PAMPs) and/or ICs-containing nucleic acids (mediated by endosomal TLRs). PAMPs or …
Comprehensive network map of interferon gamma signaling
A graphical representation of IFN-γ signaling pathway. The pathway map represents reactions of IFN-γ signaling pathway that are documented in NetPath. Different types of reactions and molecules are distinguished with different colors and arrows as provided in the legend.
Type I interferon signaling, regulation and gene stimulation in …
Type I Interferons (IFN-I) mediate numerous immune interactions during viral infections, from the establishment of an antiviral state to invoking and regulating innate and adaptive immune cells that eliminate infection.
Type I Interferon (IFN)-Regulated Activation of Canonical and …
These non-classical IFN-induced effectors have critical roles in ISG transcription, independent of or in conjunction with the canonical pathway, eliciting specific biological responses. A summary of the canonical and non-canonical pathways of type I interferon signaling is shown in Figure 1.
Interferon-gamma (IFN-γ): Reviewing its mechanisms and signaling ...
Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and regulates cellular apoptosis and proliferation.
Interferons, Interferon Receptors, Signal Transducer and ...
The interferon proteins initiate signaling by binding to their cognate receptors. The multiple human type I IFN ligands, including the IFN-α subspecies IFN-β, IFN-∊, IFN-κ, and IFN-ω, act through the shared type I receptor complex of IFNAR1 and IFNAR2 chains.