Fantasy managers may need to proceed with caution before placing San Francisco's offensive players in their lineup this week.

Star pass-catcher George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

In the San Francisco 49ers' most recent primetime appearance, All-Pro tight end George Kittle made history on two fronts in ...

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

If the San Francisco 49ers plan to knock off the Buffalo Bills in Orchard Park on Sunday night, the team will likely need ...

As for Purdy’s supporting cast, it will be without some key players. The 49ers will be missing the left side of their ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Check out the top 10 catches from San Francisco 49ers tight end George Kittle from his eight year career, so far.

Former Iowa Hawkeyes star George Kittle is in the midst of what has to be the most trying season of his NFL career. Kittle's ...

The San Francisco 49ers 2024 Salute to Service nominee, George Kittle, enthusiastically cheered on his high school teammate ...

Taysom Hill wonders if he’s the best fake tight end in the world, Will Dissly travels west to face the Falcons, and Mark ...