San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

Christian McCaffrey has been ineffective as a running back since his return. Here are a couple of contributing factors for it ...

Several star running backs received a ratings bump in Madden NFL 25 this week, including Philadelphia Eagles running back ...

The San Francisco 49ers didn’t have many changes to their Thursday practice participation report.

Speaking with reporters on Wednesday, San Francisco 49ers head coach Kyle Shanahan says it's "unfair" to expect running back ...

Christian McCaffrey, the 2023 NFL offensive player of the year, missed the first eight games of the season with an Achilles ...

Running back Christian McCaffrey says the San Francisco 49ers are “hungry” to make a playoff push even with the defending NFC ...

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

Christian McCaffrey is averaging a mere 3.5 yards per carry this season since he returned from bilateral Achilles tendonitis.

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

Christian McCaffrey has been inefficient in his three games played since dealing with Achilles tendinitis. He doesn't look ...