R289, a dual IRAK1/4 inhibitor, has received fast track status from the FDA for treating transfusion-dependent lower-risk MDS ...

Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer's disease and ordinary aging, suggests a study led ...

Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL), a commercial stage biotechnology company focused on hematologic disorders and cancer, today announced that the U.S. Food and Drug Administration (FDA) has ...

This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...

Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway. Our analysis of ecdysone-induced downstream targets ...

Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate TLRs, and what is the ...

The ion channel controls the breakdown of important proteins in endolysosomes – cell organelles that are involved in transport and degradation processes – and thus influences signaling pathways that ...

Activation of TLR signaling by viral ligands establishes primarily antiviral responses. However, certain viral infections develop TLR-mediated detrimental immunity to the host. Many viruses have ...

On immune cells, Toll-like receptors are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate ...

"For instance, it's quite possible that different molecules stimulate the same TLR but trigger different ... when the receptor switches on a certain signaling pathway in which these molecules ...

“For instance, it’s quite possible that different molecules stimulate the same TLR but trigger different responses ... when the receptor switches on a certain signaling pathway in which these ...