R289, a dual IRAK1/4 inhibitor, has received fast track status from the FDA for treating transfusion-dependent lower-risk MDS ...

Following a phase 1b trial, the potent and selective dual inhibitor of IRAK1 and IRAK4 received fast track designation for the treatment of patients with lower-risk myelodysplastic syndrome.

Rigel Pharmaceuticals, Inc. , a commercial stage biotechnology company focused on hematologic disorders and cancer, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast ...

Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL), a commercial stage biotechnology company focused on hematologic disorders and cancer, today announced that the U.S. Food and Drug Administration (FDA) has ...

Here the authors investigate whether changes in RNA structure affect TLR signaling and show that a ... BTK modulates microglial neuroinflammatory pathways relevant to multiple sclerosis (MS ...

With the discovery that vitamin D regulates the expression of an important antimicrobial peptide gene, exciting research findings are revealing and characterizing new pathways regulated by vitamin ...

Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer's disease and ordinary aging, suggests a study led ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

A basic function of cells is that they act in response to their environments. It makes sense, then, that a goal of scientists ...

S100B and Toll-like receptor (TLR) signalling converge in a common pathway leading to nitric oxide (NO) production. Results EIEC activated EGC by inducing the expression of cFos and MHC II. EGC ...

This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...