Buffalo has run consistently over the previously perceived vaunted 49ers defense to jump up to a halftime lead.

A picturesque setting of snow was the perfect backdrop for a Buffalo Bills team that has now won its fifth straight AFC East ...

The 49ers had three fumbles in Sunday night's contest, all three of which were recovered by the Bills. San Francisco's ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

The 49ers look to turn around their season with a win in Buffalo against the Bills, who are chasing the top seed in the AFC.

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

Overcoming backbreaking first-half mistakes, the Seattle Seahawks prevailed via a stellar defensive effort in a 26-21 Week 13 ...

As a steady lake-effect snowstorm pounded Orchard Park, the Bills did the same to the visiting San Francisco 49ers. Led on ...

The table is set for the Bills to clinch a fifth consecutive AFC East title in prime time on WGRZ-TV. Expect them to deliver.

San Francisco 49ers kicker Jake Moody's 33-yard field goal helps 49ers strike first on 'Sunday Night Football' against the ...

The San Francisco 49ers defense received the ball to begin tonight’s contest. Flurries came down and seemed to get worse the ...