Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

The study reveals IL-15's role in enhancing GPC3 CAR T cell therapy, improving tumor targeting and T cell survival in ...

Here, the authors show that BTK modulates microglial neuroinflammatory pathways ... signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating ...

Many groups are working today to determine which NK cell receptors influence pathology, and to understand hierarchy and integration among different receptors and signaling pathways. Translational ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

A basic function of cells is that they act in response to their environments. It makes sense, then, that a goal of scientists ...

This study investigated the conservation of 24 host protein targets, including the entry proteins ACE2 and transmembrane serine protease 2 (TMPRSS2); 21 proteins in the interferon-I (IFN-I) antiviral ...

Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB) have identified Nr1h2, a critical transcription ...

Investigators from the Mass General Brigham healthcare system will present research discoveries and outcomes from clinical trials at the 2024 American Society of Hematology (ASH) Annual Meeting, held ...

This limits the wide impact of this study but can be used as a starting point to examine sex- and age differences in the transcriptome due to alternative splicing. Complex diseases often exhibit ...

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Several lines of evidence both from experimental models and from clinical studies reveal that TNF-like ligand 1A (TL1A) and its interaction with death receptor 3 (DR3) is critically involved in ...