BAFF-R = BAFF receptor; BCMA = B-cell-maturation antigen; MS = multiple sclerosis; TACI = transmembrane activator and calcium modulator cytophilin ligand interactor. B cells are clonally expanded ...

T-cell therapy is a revolutionary immunotherapy approach in which T cells are genetically modified to express a receptor that ...

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor ...

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better ...

Diabetes drug development gets an advance in study that shows Inceptor binds excess insulin within the beta cell and directs it towards degradation.

Notably, antibodies targeting G protein-coupled receptors (GPCRs) and ion channels, both of which are transmembrane proteins, are gaining increasing attention in drug development. Transmembrane ...

GC-A is a type of single-pass transmembrane receptor protein that spans the cell membrane, connecting a binding region on the cell surface to an interior signaling domain, allowing it to transmit ...

This is best exemplified by chimeric antigen receptor (CAR) T-cells. Since first being tested in a patient nearly 15 years ago, six CAR T-cell products have been approved by the US Food and Drug ...