Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Two words can sum up the Week 12 matchup between the visiting San Francisco 49ers and the host Green Bay Packers: utter ...

The last time the 49ers were underdogs was in a Week 7 matchup with the Kansas City Chiefs on Oct. 23, 2022. San Francisco was just a 1-point underdog in that one but went on to lose 44-23.

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

San Francisco 49ers star running back Christian McCaffrey is out for the rest of 2024 after suffering a significant knee ...

San Francisco 49ers star running back Christian McCaffrey receives huge injury update following his exit from the game due to ...

If the 49ers can't break out of their funk, here are three maneuvers they should consider down the home stretch.

Temperatures reached the 20s Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Running back Josh Jacobs had three rushing touchdowns from the 1-yard line, helping the Packers finish 5-for-5 inside the red ...