Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

San Francisco 49ers star running back Christian McCaffrey is out for the rest of 2024 after suffering a significant knee ...

San Francisco 49ers star running back Christian McCaffrey receives huge injury update following his exit from the game due to ...

If the 49ers can't break out of their funk, here are three maneuvers they should consider down the home stretch.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Temperatures reached the 20s Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the ...

Orchard Park, N.Y. — The Buffalo Bills dominated the San Francisco 49ers on a snowy night at Highmark Stadium, winning 35-10 ...

The San Francisco 49ers have a laundry list of players missing in their first Week 13 practice. Nick Bosa (hip/oblique), ...

The lake-effect storm began hitting the area Saturday near the Bills’ stadium in Orchard Park, New York. Though the storm ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...