The San Francisco 49ers have slim playoff hopes of their own, but they can also play spoiler against the Buffalo Bills in ...

As the 49ers prepare for their Week 13 matchup against the Bills, Brock Purdy will be the signal caller after being listed as ...

While making updates to the team’s injury report, the San Francisco 49ers announced that left tackle Trent Williams will miss ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...

The arrow is pointing upward for Brock Purdy. On Friday, the 49ers delivered encouraging news on Purdy's status vs Buffalo in ...

Los Angeles Chargers (7-4) at Atlanta Falcons (6-5), 1 p.m. ET, FOX Atlanta holds a one-game lead over the Tampa Bay Buccaneers in the NFC South but lost the last ...

But even when most or all of those Niners took the field this year, closing out games has been a glaring weakness for a team expected to compete for the NFC. A loss to Seattle in Week 11 marked the ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

San Francisco 49ers QB Brock Purdy shared his journey through injury recovery and looked ahead to the team's Week 13 matchup ...