The main causes of acquired anemia can be divided into loss of blood (hemolysis or hemorrhage) or inadequate bone-marrow function (e.g. ineffective erythropoiesis, sideroblastic changes ...

MCV is within normal range Poikilocytosis Variation in the shape of erythrocytes May be normal in newborn period or seen in anemia due to RBC defects Polychromasia Abnormal tendency of an RBC to ...

and band 4.2. This structural membrane defect causes the red blood cells to have a spherical shape, and it can cause hemolysis (breaking down) of the red blood cells. Red blood cell hemolysis leads to ...