“Mechanistically, depletion or inactivation of the UBA1-STUB1 axis stabilized a key interferon pathway component (JAK1), enhanced IFN-signaling, and elevated key immune modulators, including CXCL9, ...

Researchers have uncovered a link between the immune gene regulator STAT1 and hyperactive behaviors in mice, offering new ...

Preclinical data demonstrate the ability of p300 KAT inhibition to modulate multiple pro-inflammatory signaling pathways, ...

“Living organisms have evolved complex pathways to sense ... further showed that the mutant Mre11 led to higher activation of interferon-stimulated genes (ISGs). Interferons are signaling molecules ...

The study reveals IL-15's role in enhancing GPC3 CAR T cell therapy, improving tumor targeting and T cell survival in ...

Discover how targeting E3-X ligase could revolutionize SLE treatment by enhancing anti-inflammatory effects while reducing ...

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR ...

"Living organisms have evolved complex pathways to sense ... Mre11 led to higher activation of interferon-stimulated genes (ISGs). Interferons are signaling molecules that are released by cells ...

"Living organisms have evolved complex pathways to sense ... Mre11 led to higher activation of interferon-stimulated genes (ISGs). Interferons are signaling molecules that are released by cells ...

The Role of JAK/STAT Pathway Activation and Its Impact on Symptoms The review looked at the constitutive activation of the JAK/STAT pathway, a signaling pathway that regulates cell growth and ...