“Mechanistically, depletion or inactivation of the UBA1-STUB1 axis stabilized a key interferon pathway component (JAK1), enhanced IFN-signaling, and elevated key immune modulators, including CXCL9, ...

The study reveals IL-15's role in enhancing GPC3 CAR T cell therapy, improving tumor targeting and T cell survival in ...

Many groups are working today to determine which NK cell receptors influence pathology, and to understand hierarchy and integration among different receptors and signaling pathways. Translational ...

Here, the authors show that BTK modulates microglial neuroinflammatory pathways ... signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating ...

This study investigated the conservation of 24 host protein targets, including the entry proteins ACE2 and transmembrane serine protease 2 (TMPRSS2); 21 proteins in the interferon-I (IFN-I) antiviral ...

A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to ...

This limits the wide impact of this study but can be used as a starting point to examine sex- and age differences in the transcriptome due to alternative splicing. Complex diseases often exhibit ...

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Several lines of evidence both from experimental models and from clinical studies reveal that TNF-like ligand 1A (TL1A) and its interaction with death receptor 3 (DR3) is critically involved in ...

The concept of inter-organ crosstalk, notably highlighted since the Nobel Prize-winning work on the Cori cycle in 1947, has significantly shaped our understanding of physiological homeostasis and ...

July 22, 2024 — The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for ...