BAFF-R = BAFF receptor; BCMA = B-cell-maturation antigen; MS = multiple sclerosis; TACI = transmembrane activator and calcium modulator cytophilin ligand interactor. B cells are clonally expanded ...

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor ...

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better ...

Notably, antibodies targeting G protein-coupled receptors (GPCRs) and ion channels, both of which are transmembrane proteins, are gaining increasing attention in drug development. Transmembrane ...

Our additional preliminary studies demonstrate that dual targeting of multiple myeloma cells and BM-CAFs by CAR-T cells is ...

GC-A is a type of single-pass transmembrane receptor protein that spans the cell membrane, connecting a binding region on the cell surface to an interior signaling domain, allowing it to transmit ...

Built with thought leaders from Seattle Genetics, Precision Biosciences and Kite Pharma, the inaugural industry-focused BCMA Targeted Therapies Summit will share the field’s cutting-edge and ...

First up is iMMagine-1, a pivotal phase 2 trial evaluating the BCMA-directed CAR-T among patients who'd received a median four lines of prior treatment. Even more recent results from the study ...