San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as "potentially" ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Running away with the AFC East: For the fifth consecutive season, the Bills are AFC East champions. This season was ...

The tragedy of this 49ers’ season epitomized. For the first time since returning to the lineup in Week 10, McCaffrey looked ...

Finally, it's over. The San Francisco 49ers suffered an abysmal 35-10 loss to the Buffalo Bills. It wasn't a close game at all for the 49ers. Buffalo was in con ...

San Francisco 49ers linebacker Fred Warner exited with cramps, but then later returned in the first half vs. the Buffalo ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

The Niners have three MVP-caliber players on offense. All have failed to live up to that standard this season.

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

That's quite a new twist added to the Calais Campbell story and how close the Miami Dolphins came to moving him at the trade ...

The Buffalo Bills are winners of six straight and welcome in last year’s Super Bowl runner-up, the San Francisco 49ers on ...