Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

The San Francisco 49ers will host the Chicago Bears on Sunday at 4:25 p.m. ET.The 49ers fell to the Buffalo Bills 35-10 in ...

San Francisco 49ers star running back Christian McCaffrey is out for the rest of 2024 after suffering a significant knee ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

San Francisco 49ers star running back Christian McCaffrey receives huge injury update following his exit from the game due to ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The lake-effect storm began hitting the area Saturday near the Bills’ stadium in Orchard Park, New York. Though the storm ...

Temperatures reached the 20s Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the ...

Learn which TV channel or how to live stream the NFL Week 13 Buffalo Bills and San Francisco 49ers game, Sunday, Dec. 1.

If the 49ers can't break out of their funk, here are three maneuvers they should consider down the home stretch.

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.