Wang et al. decreased mortality from sepsis in mice, using nicotine to activate the cholinergic anti-inflammatory pathway.

The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to ...

While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that ...

Inflammation and coagulation are closely linked in sepsis. Inflammatory mediators generate tissue factor expression and initiate coagulation through activation of the extrinsic pathway ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

We investigated lectin pathway cord blood concentrations in infants with neonatal sepsis. Study design: Case-control study including 47 infants with culture-proven neonatal sepsis and 94 matched ...