McCaffrey suffered what the 49ers called a knee injury and gave up on his final carry. It was a sad scene for a player who ...

The San Francisco 49ers defense received the ball to begin tonight’s contest. Flurries came down and seemed to get worse the ...

San Francisco 49ers kicker Jake Moody's 33-yard field goal helps 49ers strike first on 'Sunday Night Football' against the ...

The 49ers look to turn around their season with a win in Buffalo against the Bills, who are chasing the top seed in the AFC.

Buffalo has run consistently over the previously perceived vaunted 49ers defense to jump up to a halftime lead.

We could be looking at a Winter Wonderland in Buffalo when the Bills host the 49ers in a December affair with playoff ...

The Bills will look to resume its path to the No. 1 seed in the AFC with MVP front runner Josh Allen leading the charge. ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

If the 49ers can't break out of their funk, here are three maneuvers they should consider down the home stretch.

The Week 13 Sunday slate closes with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6) on Sunday Night Football.

Josh Allen is currently the frontrunner in NFL MVP odds, and we expect the Bills superstar quarterback to use his athleticism ...

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio ...