Nature1mon
Wnt signalling and its impact on development and cancer
These signalling systems operate beyond cell ... Figure 3: Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so-called cancer stem cells, which ...
Hosted on MSN11mon
Wnt pathway dysfunction influences colorectal cancer response to immunotherapy, finds study
Intriguingly, the expression of the MLH1 gene, crucial for DNA repair, was influenced by the activity of the Wnt signaling pathway. In MSI patients, the canonical Wnt signaling pathway was notably ...
eLife10d
Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength
Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...
Nature1mon
A special issue on cell signaling, disease, and stem cells
Cell signaling is also pivotal for multi-cellular ... their identification of a novel small molecule agonist of the canonical Wnt pathway and its use in modulation of MSC differentiation; and ...