Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth ...

San Francisco 49ers three-time Super Bowl champion has suddenly passed away at 80, the team announced on Thursday.

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Amid a wicked Super Bowl hangover and heading towards what is likely a losing season, it’s natural that head coach Kyle ...

The San Francisco 49ers have lost back to back games and are losers in three of their last five, falling to 5-6 on the season ...

John and Jim Harbaugh have met as head coaches on the biggest stage in football, colliding back in Super Bowl 47.

The banged-up 49ers suffered a blowout loss to the Packers on Sunday, and their playoff outlook is becoming more bleak.

The 49ers have two divisional games left on the schedule. In Week 15, they host the Los Angeles Rams on Thursday night. In ...

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

For as up and down as the San Francisco 49ers have been as a franchise ever since Steve Young retired, we are firmly in the ...