The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as "potentially" ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

Defeating the Buffalo Bills on the road will be extremely difficult for the San Francisco 49ers. Going to the East Coast when ...

The tragedy of this 49ers’ season epitomized. For the first time since returning to the lineup in Week 10, McCaffrey looked ...

Discover the greatest RBs in San Francisco 49ers history: from Super Bowl heroes to game-changing performers, find out who ...

Finally, it's over. The San Francisco 49ers suffered an abysmal 35-10 loss to the Buffalo Bills. It wasn't a close game at all for the 49ers. Buffalo was in con ...

The Niners have three MVP-caliber players on offense. All have failed to live up to that standard this season.

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The San Francisco 49ers are expecting to get star tight end George Kittle back this week for a key game against Green Bay, ...

The San Francisco 49ers were without a host of key players Sunday against the Green Bay Packers, but their problems ran much ...