The chief executive of UnitedHealthcare, one of the nation’s largest insurers, was killed in midtown Manhattan in what police described as a targeted attack.

Leaders from Minnesota are reacting to the fatal shooting of UnitedHealthcare chief executive officer Brian Thompson outside a New York City hotel Wednesday morning.

The CEO of UnitedHealthcare, one of the largest insurance providers in the nation, was fatally shot Wednesday morning outside the Hilton hotel in midtown Manhattan in what police said was a "brazen targeted attack.

Brian Thompson, chief executive of UnitedHealthcare, was fatally shot Wednesday morning in front of a midtown hotel, the New York Post and New York Times reported, citing police sources.

Police have not identified the suspect, who remains on the loose and was last seen riding an electric Citibike in Central Park, officials said.